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27 Termination Agreement between the company and Louis Mancini.

The orphan designation offers a number of advantages, including product tax credits, marketing incentives, and a period of exclusivity. Phase 4: In this phase the product is already on the market and ongoing monitoring is undertaken to observe for any new short-term or long-term effects. In some cases new data has resulted in products being taken off the market, most notably in the case of the drug Vioxx marketed by Merck amp; Co. Vioxx was a widely used anti-inflammatory drug used to treat acute and chronic pain related to arthritis.

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